Yan Burelle

Carte électronique

Yan Burelle
Professeur titulaire

University Research Chair in Integrative Mitochondrial Biology
Department of Cellular and Molecular Medicine, Faculty of Medicine
2002: Post-Doctoral Fellowship, Comparative Biochemistry, University of British-Columbia
2000: Ph.D., Exercise Physiology, Université de Montréal

Room : RGN 2118

Courriel professionnel : yburell2@uottawa.ca

Biographie

Les dysfonctions mitochondriales sont au centre d’un grand nombre de pathologies d’origine génétique ou acquise. L’objectif du Dr. Burelle est de mieux comprendre les mécanismes complexes qui lient la biologie de ces organelles cellulaires à la santé et aux pathologies humaines. En utilisant des outils et des modèles de recherche fondamentale ainsi que des approches translationnelles non-invasives, son laboratoire cherche à étudier la diversité et la dynamique des (dys)fonctions mitochondriales dans le contexte de cardiopathies, de myopathies et de maladies mitochondriales héréditaires. Son laboratoire s’intéresse également à l’analyse clinique des fonctions mitochondriales afin d’obtenir des biomarqueurs métaboliques/mitochondriaux pouvant servir au diagnostic et au suivi des patients.

 

Intérêts de recherche

  • Role of mitochondria in acquired and genetic cardiomyopathies
  • Role of mitochondria in acquired and genetic skeletal muscle disorders
  • Pathogenesis of genetic mitochondrial diseases
  • Bioenergetics
  • Mitochondrial quality control
  • Oxidative stress

 

Liens utiles

 

Publications

  • Picard M, Wallace DC, Burelle Y. The rise of mitochondria in medicine. Mitochondrion. 2016 Jul 14;30:105-116. doi: 10.1016/j.mito.2016.07.003, PubMed PMID: 27423788.
  • Matheoud D, Sugiura A, Bellemare-Pelletier A, Laplante A, Rondeau C, Chemali M, Fazel A, Bergeron JJ, Trudeau LE, Burelle Y, Gagnon E, McBride HM, Desjardins  M. Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation. Cell. 2016 Jun 21. doi: 10.1016/j.cell.2016.05.039. [Epub ahead of print] PubMed PMID: 27345367.
  • Cadete VJ, Deschênes S, Cuillerier A, Brisebois F, Sugiura A, Vincent A, Turnbull D, Picard M, McBride HM, Burelle Y. Formation of Mitchondrial-derived vesicles is an active and physiologically relevant mitochondrial quality control  process in the cardiac system. J Physiol. 2016 Jun 17. doi: 10.1113/JP272703. [Epub ahead of print] PubMed PMID: 27311616.
  • Klionsky DJ, …Burelle Y …Zughaier SM, Guidelines for the use and interpretation of assays for monitoring autophagy (3rdedition). Autophagy. 2016 Jan 2;12(1):1-222.
  • Song M, Gong G, Burelle Y, Gustafsson AB, Kitsis RN, Matkovich SJ, Dorn GW 2nd. Interdependence of Parkin-Mediated Mitophagy and Mitochondrial Fission in Adult Mouse Hearts. Circ Res. Jul 31; 117(4):346-51, 2015
  • Picard M, Azuelos I, Jung B, Giordano C, Matecki S, Hussain S, White K, Li T, Liang F, Benedetti A, Gentil BJ, Burelle Y, Petrof BJ. Mechanical ventilation triggers abnormal mitochondrial dynamics and morphology in the diaphragm. J Appl Physiol (1985). May 1;118(9):1161-71, 2015
  • Marton J, Albert D, Wiltshire SA, Park R, Bergen A, Qureshi S, Malo D, Burelle Y, Vidal SM. Cyclosporine A Treatment Inhibits Abcc6-Dependent Cardiac Necrosis and Calcification following Coxsackievirus B3 Infection in Mice. PLoS One. Sep 16;10(9):e0138222, 2015
  • Thompson Legault J, Strittmatter L, Tardif J, Sharma R, Tremblay-Vaillancourt V, Aubut C, Boucher G, Clish CB, Cyr D, Daneault C, Waters PJ; LSFC Consortium, Vachon L, Morin C, Laprise, C, Rioux JD, Mootha VK, Des Rosiers C. A Metabolic Signature of Mitochondrial Dysfunction Revealed through a Monogenic Form of Leigh Syndrome. Cell Rep. Nov 3;13(5):981-9, 2015
  • Burelle Y, Bemeur C, Rivard ME, Thompson-Legault J, Boucher G, LSFC Consortium, Morin Charles, Coderre L3, Des Rosiers C. Mitochondrial Vulnerability and Increased Susceptibility to Nutrient-Induced Cytotoxicity in Fibroblasts from Leigh Syndrome French Canadian Patients. Plos One, accepted, 2015
  • Gouspillou G, Sgarioto N, Norris B, Barbat-Artigas S, Aubertin-Leheudre M,Morais JA, Burelle Y, Taivassalo T, Hepple RT. The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans. PLoS One. Aug, 14;9(8), 2014
  • Maltais F, Decramer M, Casaburi R, Barreiro E, Burelle Y, Debigare R , Dekhuijzen RPN,. Franssen, F, Gayan-Ramirez G, Gea J, Gosker HR, Gosselink R, Hayot M, Hussain SNA, Janssens W, Polkey, MI, Roca J, Saey D, Schols AMWJ, Spruit MA, Steiner M, Taivassalo T, Troosters T, Vogiatzis I, Wagner PD on behalf of the ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD. An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. Am. J. Resp. Crit. Care. In press
  • Isner-Horobeti ME, Rasseneur L, Lonsdorfer-Wolf E, Dufour SP, Doutreleau S,Bouitbir J, Zoll J, Kapchinsky S, Geny B, Daussin FN, Burelle Y, Richard R. Effect of eccentric vs concentric exercise training on mitochondrial function. Muscle Nerve. Feb 20. 2014
  • Gouspillou G, Picard M, Godin R, Burelle Y, Hepple RT. Role of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in denervation-induced atrophy in aged muscle: facts and hypotheses. Longev Healthspan. Aug 1; 2(1):13. 2013
  • Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW 2nd. Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res. Jan 17; 114 (2):257-65. 2014
  • Piquereau J, Godin R, Deschênes S, Lafrenière Bessi V, Mofarrahi M, Hussain SNA, Burelle Y. Protective role of Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction. Autophagy 9: 1837-1851, 2013
  • Mofarrahi M, Guo Y, Haspel JA, Choi AMK, Davis EC, Gouspillou G, Hepple RT, Godin R, Burelle Y, Hussain SNA. Autophagic flux and oxidative capacity of skeletal muscle during acute starvation. Autophagy 9(10) 1604-1620, 2013
  • Picard M, Shirihai OS, Gentil BJ, Burelle Y. Mitochondrial Morphology Transitions and Functions: Implications for retrograde Signaling? Am J Physiol Regul Integr Comp Physiol. Jan 30, 2013
  • Mofarrahi M, Sigala I, Guo Y, Godin R, Davis EC, Petrof B, Sandri M, Burelle Y*, Hussain SN*. Autophagy and skeletal muscles in sepsis. PLoS One. 7(10). 2012 *Co-senior authors
  • Picard M, Jung B, Liang F, Azuelos I, Hussain S, Goldberg P, Godin R, Danialou G, Chaturvedi R, Rygiel K, Matecki S, Jaber S, Des Rosiers C, Karpati G, Ferri L, Burelle Y, Turnbull DM, Taivassalo T, Petrof BJ. Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation. Am J Respir Crit Care Med. 2012 Dec 1; 186(11):1140-9. 2012
  • Godin R, Daussin F, Matecki S, Li T, Petrof BJ*, Burelle Y*. Peroxisome proliferator-activated receptor coactivator 1- gene transfer restores mitochondrial biomass and improves mitochondrial calcium handling in post-necrotic mdx mouse skeletal muscle. J Physiol. 1;590(Pt 21):5487-502., Nov 2012 *Co-senior authors
  • Pauly M, Daussin F, Burelle Y, Li T, Godin R, Fauconnier J, Koechlin-Ramonatxo C, Hugon G,Lacampagne A, Coisy-Quivy M, Liang F, Hussain S, Matecki S, Petrof BJ. AMPK activation stimulates autophagy and ameliorates muscular dystrophy in the mdx mouse diaphragm. Am J Pathol. Aug;181(2):583-92, 2012
  • Picard M, Burelle Y. Mitochondria: starving to reach quorum? Insight into the physiological purpose of mitochondrial fusion. Bioessays. Apr; 34(4):272-4. 2012
  • Picard M, Hepple RT, Burelle Y. Mitochondrial functional specialization in glycolytic and oxidative muscle fibers: tailoring the organelle for optimal function. Am J Physiol Cell Physiol. Feb 15; 302(4):C629-41. 2012
  • Daussin FN, Rasseneur L, Bouitbir J, Charles AL, Dufour SP, Geny B, Burelle Y, Richard R. Different timing of changes in mitochondrial functions following endurance training. Med Sci Sports Exerc. Feb; 44(2):217-24. 2012
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